NSH Hospital, Maharashtra, has achieved a significant milestone in the medical field by successfully performing India’s first Haplo Bone Marrow Transplant for a patient with LIG4 deficiency. It is a rare genetic disorder caused by a mutation that impairs the ability of body to repair broken DNA, leaving patients highly vulnerable to infections, developmental issues, and bone marrow failure.
LIG4 deficiency is uncommon, and only around 10 such cases have ever been reported worldwide; that’s why treatment is complex and successful transplants are extremely rare.
The procedure was performed on a 19-year-old patient by a multidisciplinary team at NSH Hospital. Haploidentical transplants, which use a half-matched family donor, are more challenging than fully matched donor transplants. The added step of T-cell depletion further reduces the risks of rejection and graft-versus-host disease, but it requires advanced expertise, precise laboratory support, and intensive perioperative care.
Specialists from neurology, cardiology, radiology, gynecology, and pediatrics collaborated to ensure a smooth transplant process. The team stated that the patient is responding well in the early post-transplant phase, but close monitoring will be required for the next two months.
This achievement marks a major step forward for India’s bone marrow transplant capabilities and highlights the growing strength of complex cellular therapy in the country.
Know more:- Bone Marrow Transplant cost in India
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