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Acromegaly Treatment in India

Acromegaly is a hormonal condition that occurs when your pituitary gland releases excessive amounts of growth hormone in adulthood.

When you have excessive growth hormone, your bones develop in size. This causes gigantism in children. In adulthood, however, there is no variation in height. Instead, the growth in bone size is limited to the bones of your hands, feet, and face, and is known as “Acromegaly in India”.

When high levels of growth hormone are left untreated, it can impact other sections of the body in addition to your bones. This can result in serious, even life-threatening, health complications. However, Acromegaly Treatment in India may reduce your chance of developing issues and considerably improve your symptoms, including facial enlargement.

What Is Acromegaly Condition

Acromegaly is a rare but devastating medical disorder caused by excessive levels of growth hormone (GH) in the body. Acromegaly is caused by tumors on your pituitary gland or in other parts of your body that create excess GH.

The pituitary gland is a small pea-sized endocrine gland observed near the base of the brain, beneath the hypothalamus. Your pituitary gland secretes eight essential hormones, one of which is GH.

Growth hormone, also known as Human Growth Hormone (hGH) and somatotropin, is a natural hormone that promotes growth in children by acting on many different regions of the body. Once your bones’ growth plates (epiphyses) have fused, GH ceases to promote height, but your body still requires it. After you’ve stopped growing, GH helps to maintain proper bone, cartilage, and organ structure and metabolism, including maintaining healthy blood glucose (sugar) levels.

As an adult, having too much GH in your body can cause abnormally shaped bones, enlarged organ size, raised blood sugar levels (hyperglycemia), and other symptoms.

Acromegaly (extra growth hormone) causes bones, cartilage, bodily organs, and other tissues to increase in size in adulthood. Changes in appearance include larger hands, feet, ears, lips, and nose, as well as a more prominent jaw and forehead.

Growth hormone (GH) stimulates the production of another hormone known as insulin-like growth factor 1 (IGF-1). IGF-1 is the hormone that stimulates bone and tissue growth as well as influences how your body handles blood glucose (sugar) and lipids (fats). High GH levels cause high IGF-1 levels, which can lead to Type 2 diabetes, high blood pressure (hypertension), and heart disease.

What Are the Symptoms of Acromegaly

Acromegaly affects the bones and tissues of adults, causing them to grow in an inconsistent manner.

Signs and Symptoms of Acromegaly in Adulthood are following :

  • Hands or feet that are larger than normal.
  • Changes in your facial form, such as a larger jaw and/or forehead.
  • Expand the size of your lips, nose, and/or tongue.
  • Sweating excessively or having oily skin.
  • Your voice is becoming stronger and louder.

Other signs and symptoms include:

  • Headaches.
  • Joint discomfort.
  • Vision shifts.
  • The amount of skin tags has increased.
  • You have numbness in your hands.
  • Apnea when sleeping.
  • Carpal tunnel syndrome or problems with the spinal cord.

Acromegaly symptoms frequently appear gradually and may be difficult to detect at first. Some people find out their hands have grown in size when rings they habitually wear become too tight or their shoe size, particularly the width, changes.

If you are having the above mentioned symptoms, you should consult with your doctor immediately. Acromegaly usually develops steadily. Even your family members may miss the minor physical changes caused by this condition at first. However, early diagnosis is important so that you can begin receiving adequate care. If untreated, acromegaly can cause major health complications.

What Are the Causes of Acromegaly

The most common Cause of acromegaly is a pituitary adenoma, which causes your pituitary gland to release excessive growth hormone (GH).

The pituitary gland is a small gland situated at the base of your brain, behind your nose bridge. It is responsible for the production of GH as well as a variety of other hormones. GH plays an important role in controlling your physical growth.

Pituitary adenomas (tumors) are usually always noncancerous (harmless). Most adenomas that cause acromegaly grow slowly, and signs of excess GH may not appear for several years.

The adenoma may press against other pituitary tissue and disrupt with other hormones produced by your pituitary gland, depending on its size and location. If the adenoma is large, it may press against surrounding brain areas, causing headaches and vision issues.

How Is the Diagnosis of Acromegaly Done

Your doctor will ask about your medical history and perform a physical examination. Then he or she may suggest the following measures for the diagnosis of Acromegaly:

  • IGF-1 Levels Measurement: After you’ve fasted overnight, your doctor will collect a blood sample to figure out the level of IGF-1 in your blood. A high IGF-1 level signifies acromegaly.
  • Growth Hormone Suppression Test: It is the most accurate way of verifying an acromegaly diagnosis. During this test, your GH blood level is determined both before and after you drink a sugar (glucose) preparation. The glucose drink often causes the GH level to fall in persons who do not have acromegaly. However, if you have acromegaly, your GH level will remain elevated.
  • Imaging tests: Such as magnetic resonance imaging (MRI), may be recommended by your doctor in order to pinpoint the location and size of a tumor on your pituitary gland. If there are no pituitary tumors found, your doctor may conduct additional imaging tests to screen for non pituitary tumors.

If you’ve been diagnosed with acromegaly, your doctor may recommend additional testing to see whether the problem has spread to other parts of your body. Among these tests are:

  • An echocardiography is used to diagnose cardiac problems.
  • Sleep study tests are used to detect sleep apnea.
  • A colonoscopy is used to evaluate the health of your colon.
  • X-rays or a DEXA (DXA) scan can be used to evaluate bone health.

Acromegaly Treatment Cost in India

Affordable Acromegaly Treatment Cost in India starts from INR 4,75,000 (5,700 USD). After the treatment in India, your hospital stay is 4 days and seven days beyond the hospital. Factors that can affect Acromegaly Treatment Cost in India: Based on the size and location of the tumor, a method employed for elimination, the success rate is greater than 95%. Factors Affecting the Cost of Acromegaly Treatment in India are the following: 

  • The type of hospital chosen by the patient
  • Room –Standard single room, deluxe room, super deluxe room for the number of nights specified (including nursing fee, meals, room rate, and room service).
  • Operating room, ICU
  • Fee for the team of doctors 
  • Medicines
  • Standard test and diagnostic procedures

Depending on the treatment options :

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Procedure

How is the Treatment of Acromegaly in India Done?

There are various Treatments Available for Acromegaly in India. Your medical professional will evaluate your symptoms and circumstances before recommending treatment alternatives that are appropriate for you. The most common Treatments Options for Acromegaly in India include surgery, medication, and radiation therapy.

Treatments for Acromegaly

Surgery

Transsphenoidal surgery is a procedure performed to Treat Acromegaly in India. Transsphenoidal Surgery in India is a type of surgery in which the surgeon performs the process via the patient’s nose and sphenoid sinus, a hollow space in the skull located below the brain and behind the nasal passages.

The details of the surgical procedure will be determined by the size and location of the tumor. The goal of surgery is to entirely remove a tumor that produces an excessive amount of growth hormone. If your surgeon is able to remove enough of the tumor, you may not need any extra treatment. If the surgeon only removes a piece of the tumor, you may need medication or radiation therapy to suppress the generation of growth hormones.

Medications

Your doctor may recommend a single medicine or a group of Acromegaly Treatment Drugs. The various medications work in different ways to keep your body’s growth hormone levels normal and minimize your symptoms. In some situations, patients may be advised to take the medications until the tumor has shrunk to the point that the surgeon may safely remove it.

Radiation Therapy

Medical doctors recommend radiation therapy to remove any remaining cancer cells and gradually reduce GH levels. The radiation technique provides three alternative approaches to treat acromegaly, and symptoms may improve gradually over months or even years. Stereotactic radiosurgery, proton beam therapy, and conventional radiation therapy are among the techniques used.

What Are the Complications of Acromegaly?

Acromegaly, if left untreated, can lead to the following complications:

  • Diabetes type II.
  • Hypertension (high blood pressure).
  • Cardiovascular disorders.
  • Cardiomyopathy is a disorder of the heart muscle.
  • Arthritis.
  • If left untreated, colon polyps can develop into colon cancer.
  • Failure of an organ.

The life expectancy of someone with acromegaly is determined by the severity of the disease and whether they have other health problems, which are frequently caused by untreated acromegaly.

Outlook

Acromegaly is a rare but serious disorder. The good news is that it is curable by surgery, medicine, and/or radiation therapy. It’s important to consult your doctor if you’ve noticed an increase in the size of your hands, feet, or facial features. They can perform a few basic tests to see whether your growth hormone levels are the source of your symptoms. If there are no symptoms of acromegaly and the person is fit and fine despite being taller than average, there is no reason for seeking treatment. Many people have a higher rate of growth hormone secretion, yet there may be no consequences. The individual is then not needed to receive any treatment.

The Most Important Frequently Asked Questions

Q: What Is the Most Prevalent Acromegaly Treatment?

A: Somatostatin analogues (SSAs) are the most commonly used medications to treat acromegaly. These medications inhibit the release of GH and may help to shrink the pituitary tumor. Several studies have proven that these medications are both safe and effective for long-term use.

Q: What Is the First Acromegaly Treatment?

A: Transsphenoidal pituitary surgery is usually the first-line treatment for acromegaly patients. Patients with larger and more invasive tumors (macroadenomas) are less likely to be in remission after surgery.

Q: Which Doctors Treat Acromegaly?

A: Acromegaly can be treated with hormone-suppressing medications or radiation to decrease a pituitary tumor, but surgery by neurosurgeons and otolaryngologists (ENT) is the first-line treatment. Acromegaly is usually cured by removing the pituitary tumor.

Q: What Is Another Name for Acromegaly?

A: Gigantism, also called pediatric acromegaly and pituitary gigantism, is a very rare condition that happens when a child or adolescent has high levels of growth hormone (GH) in their body, which causes them to grow very tall.

Q: What Is the First Acromegaly Test?

A: The initial step in diagnosing acromegaly is biochemical screening. To diagnose and rule out acromegaly, Endocrine Society guidelines and expert consensus propose utilizing age- and sex-adjusted IGF-1 values in conjunction with GH nadir during an oral glucose tolerance test (OGTT).

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