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Primary CNS lymphoma is a type of malignant cancer that develops in the lymph tissues of the spinal cord or brain. It is a rare type of non-Hodgkin lymphoma of the central nervous system and eye, accounting for 1% of all intracranial tumors. Other names for primary central nervous system lymphoma (PCNSL) include reticulum cell sarcoma, diffuse histiocytic lymphoma, and microglioma. Unlike other brain tumors, it often has a favorable response to both chemotherapy and radiation therapy thus for (PCNSL) primary CNS lymphoma treatment in India doctors mostly focus on treating patients with chemo and radiation.

The cost of Primary CNS Lymphoma treatment in India is less expensive than in other counties, and it includes high-tech equipment and the world’s best specialists. Not only that, but treatments for Primary CNS Lymphoma in India are available at affordable prices with high treatment quality.

What Is Primary CNS Lymphoma?

Lymphoma is cancer that begins in the lymphocytes. These cells are located in the spleen, thymus, bone marrow, lymph nodes, and other organs. When you have lymphoma, your lymphocytes can change and grow out of control. Lymphoma consists of two types:

  • HodgkinLymohoma
  • Non- Hodgkin lymphoma

Both Hodgkin’s and Non-Hodgkin’s lymphoma are cancers that begin in a subset of white blood cells called lymphocytes. The difference between Hodgkin’s and non-Hodgkin’s lymphoma is in the various lymphocytes involved in each.

Primary Central Nervous System (CNS) Lymphoma is a disease in which malignant (cancer) cells form in the brain and/or spinal cord lymph tissue. Patients with acquired immunodeficiency syndrome (AIDS) or other immune system disorders, as well as those who have had an organ transplant, are at risk of developing primary CNS lymphoma.

What Are the Signs and Symptoms of Primary CNS Lymphoma?

The symptoms vary depending on where the tumors are located. The following are some of the most common signs and symptoms of Primary CNS lymphoma:

  • Vomiting and nausea
  • Seizures
  • Headaches
  • Weakness in one’s arm or leg
  • Confusion
  • Dubious vision
  • Hearing impairment

If you experience any of the symptoms listed above, contact your doctor or physician.

What Exactly Causes Primary CNS Lymphoma?

Doctors have still yet to find the exact cause of primary CNS lymphoma. But since primary CNS lymphoma of the brain arises from cells of the immune system, people with a certain genetic disease and impaired immune system or infectious disease are most at risk of developing this form of cancer. 

Here are some of the risks that may cause the disease:

  • Weak immune system
  • Infection
  • Autoimmune disease
  • Radiation
  • Age
  • Family history or genetics
  • Chemical exposure.

Certain conditions associated with a weakened immune system may increase your chances of developing CNS lymphoma. They are as follows:

  • HIV/AIDS (especially if you have an active Epstein-Barr infection) 
  • Wiskott-Aldrich Syndrome (WIS).
  • Combined Variable immunodeficiency syndrome (CVID).
  • Ataxia Telangiectasia

Taking immunosuppressive medications after an organ transplant may increase your risk of developing certain cancers, including CNS lymphoma.

Primary CNS Lymphoma Treatment Cost In India

On average, Primary CNS Lymphoma Treatment Cost in India starts from USD 1800. The type of procedure you choose will vary in Primary CNS Lymphoma Treatment Cost in India.

Types of Treatment Procedures for Treating Primary CNS Lymphoma Treatment in India

Treatment Starting Price
Radiation therapy USD 4200
Chemotherapy USD 3500
Steroid therapy USD 144
Target therapy USD 2800
High-dose chemotherapy with stem cell transplant USD 4000

Estimated prices depending on different cities in India

Cities Starting Price
Delhi USD 1800
Gurgaon USD 1900
Noida USD 2200
Mumbai USD 2400
Hyderabad USD 1800
Chennai USD 1800
Kolkata USD 1900
Bangalore USD 2200

Note: Do remember that the pricing and the treatment for Primary CNS Lymphoma Treatment cost in India will vary depending on the patient’s choice and other various factors.

Factors That Can Affect Primary CNS Lymphoma Treatment Cost in India

The following here are some variables that can affect Primary CNS Lymphoma Treatment Cost in India:

  • Medication costs.
  • Duration of treatment.
  • Geographical location.
  • Hospitalization expenses.
  • Government policies and subsidies.
  • Medical tourism packages.
  • Hospital reputation and infrastructure.
  • The expertise and experience of medical professionals.
  • The type and frequency of diagnostic procedures.
  • The choice of treatment modality.

Furthermore, even the standard and grade of medical care and amenities are comparable to those of the most prestigious healthcare facilities in the world, even when the expense of lodging, meals, and transportation is taken out. Also, under the direction of the most skilled physicians, Medsurge India provides patients with the lowest Primary CNS Lymphoma Treatment Cost in India.

How Is Primary CNS Lymphoma Diagnosed?

A neurological examination is usually performed to evaluate symptoms. This includes testing swallowing, hearing, sense of smell, eye movements, sensation, balance, coordination, and so on, as well as an eye exam to assess eye health and identify any problems.

Your doctor might use the following types of tests to diagnose CNS lymphoma:

  • Magnetic resonance imaging (MRI): uses magnets to view the blood flow in the brain.
  • Physical exam health history: Your physician will ask about your symptoms and family medical history. A neurological exam will be performed to look for signs of CNS lymphoma.
  • Lumbar puncture: A needle is inserted into your spine to withdraw cerebrospinal fluid.
  • Eye exam: Your doctor may dilate the pupils and look through the eye with special equipment to check for signs of tumors or cancer. In some cases, they may repeat this exam to help track changes or measure the growth of the tumor.
  • Blood work: Your physician may perform a complete blood count to look for abnormalities in your immune system and may also check for HIV, which is a risk factor for lymphoma.
  • Biopsy: A sample of a suspected tumor is given to check for cancerous cells to the lab technicians.

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What Are the Treatments Options for Primary CNS Lymphoma Patients?

Patients with primary CNS lymphoma can choose from a variety of treatment options. Some are standard, i.e. currently used treatments, while others are in trials. It is important to note that surgery is not used to treat primary CNS lymphoma, but rather to help extend your life or improve your quality of life.

The four most common treatments for primary CNS lymphoma in India are as follows:

Radiation therapy: High-energy x-rays or other types of radiation are used in these treatments to kill cancer cells and prevent them from growing. External radiation therapy employs a machine located outside the body to deliver radiation to the cancerous area.

Chemotherapy: These treatments use drugs to stop the growth of cancer cells in the body by killing or preventing them from dividing. Chemotherapy can be administered orally or through injections into veins or muscles. Chemotherapy will be administered differently depending on whether the tumor is in the CNS or the eye.

Steroid therapy: Steroids are hormones that are produced naturally in the body but can also be manufactured in a laboratory and used as drugs. They may also aid in the treatment of some cancer-related side effects, such as vision problems. Glucocorticoids are steroid medications that have an anticancer effect in lymphomas.

Target therapy: Drugs or other substances are used in target therapy to identify and attack specific cancer cells. This treatment is less harmful to normal cells than chemotherapy or radiation therapy.

High-dose chemotherapy with stem cell transplant: Patients are given high-dose chemotherapy to kill cancer cells. Because cancer treatments destroy cells such as blood-forming cells, stem cell transplantation is used to help replace them in patients with primary CNS lymphoma. Immature blood cells are extracted from the patient’s or donor’s blood and frozen or stored. When the patient’s chemotherapy is finished, the stored stem cells are returned to the patient via infusion, and these stem cells are reinfused to restore or grow in the body’s blood cells.

In today’s world, new treatments are being tested in clinical trials which are tested for the treatment of patients with primary CNS lymphoma in India. Here are some new treatments for Primary CNS Lymphoma that your doctor may incorporate into your treatment plan:

  • Whole brain radiation therapy
  • Clinical trials of high-dose chemotherapy and stem cell transplant
  • Clinical trials of high-dose chemotherapy with or without stem cell transplant or targeted therapy
  • Clinical trials of chemotherapy followed by whole-brain radiation therapy or high-dose chemotherapy.

Various studies have shown that combining treatments such as whole-brain radiation therapy and other therapies improves outcomes. Neurological complications can arise as a result of the indirect or direct effects of leukemia and lymphoma.

 The cost of Primary CNS Lymphoma surgery in India is determined by several factors, including

  • The condition’s severity
  • The hospital’s location and accreditations were chosen.
  • Experience as a surgeon
  • Duration of hospital stay 
  • Room type
  • Any additional procedures are needed


Early diagnosis and treatment of PCNSL are critical to maintaining neurological and cognitive function and quality of life. To avoid further delays, it is critical to identify neurologic complications from leukemia and lymphoma as soon as possible and find appropriate treatments. It can be shocking to discover that you or someone close to you has PCNSL. Nonetheless, you are not alone. You can consult or seek advice from your healthcare provider, who will provide you with the tools, equipment, and resources you will need to care for yourself or your family.

Medications: Monoclonal antibodies such as rituximab and nivolumab are used to treat newly diagnosed or recurrent primary CNS lymphoma, while common opioids such as Tramadol (Ultram), Hydromorphone (Dilaudid), and Methadone (Dolophine, Methadose) are used to relieve pain.

How Can Medsurge India Help?

Medsurge India is a prestigious support system for patients looking for doctors, hospitals, and specialized treatments. We’ll find the most suitable medical options for you. Regarding your medical issues, our team will give you a list of certified, reputable, and trusted doctors and hospitals. Additionally, we offer a treatment strategy that fits your budget. Apart, we assist patients with obtaining travel authorizations, medical visas, and a multitude of other things.

The Most Important Frequently Asked Questions

Q: What Stage Is Primary CNS Lymphoma?

A: (PCNSL) Primary Central Nervous System lymphoma is a stage 1 disease. 

Q: Can Primary CNS Lymphoma Be Cured?

A: It can be found in the cerebrum, eyes, and leptomeninges and very rarely in the spinal cord. For CNS lymphoma treatment doesn’t aim to cure as there are no available treatments that can cure the disease. But the goal is to extend the life and improve the quality of life.

Q: Who Gets Primary CNS Lymphoma?

A: Primary CNS lymphoma is mostly seen in people over 50 years, with an average age of diagnosis at 65. PCNSL is more common in men and people assigned male at birth and people with HIV/AIDS and immunodeficiencies, etc.

Q: Can Primary CNS Lymphoma Spread?

A: As these are known to be malignant tumors they can spread to other sites of the body. 

Q: Does CNS Lymphoma Return?

A: CNS lymphoma is an invasive malignant lymphoma bound to the central nervous system. Even after treatments, it can still relapse within a period of 2 years.

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