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Car T-Cell Therapy Cost in India

Chimeric antigen receptor (CAR) T-cell therapy is a method of modifying immune cells called T cells (a type of white blood cell) in the lab so that they can detect and destroy cancer cells. Because it includes changing the genes inside T cells to help them attack cancer, CAR T-cell therapy is sometimes referred to as a type of cell-based gene therapy. This Car T-cell therapy in India can be quite beneficial in the treatment of certain types of cancer, even when other treatments have failed. CAR T cell therapy is a cutting-edge treatment for blood cancers such as leukemia and lymphoma. The therapy has given hope to cancer patients in difficult situations when normal treatments such as chemotherapy and radiation have failed to eliminate the disease.

One of the most significant challenges is the cost of CAR T-cell therapy in India, which has financial consequences for patients, payers, and providers. The most expensive part of CAR T-cell therapy is the medicine itself. 

What is Car T-Cell Therapy?

CAR T-cell therapy is a form of immunotherapy that uses genetically modified immune cells to fight cancer. T cells are white blood cells that have been genetically engineered to locate and target cancer cells in the body.

According to the immune system, this powerful army of T-cells serves as the front line of our body’s defenses. Their aim is to find and eliminate anything that can cause disease or infection. When it comes to cancer, the immune system frequently fails to deploy T-cells quickly or at all. When this happens, the attack is considered unusable. CAR T-cell therapy in India transforms these T-cells into chimeric antigen receptors (or CARs), which bind to cancers and kill them.

About T-cells: By understanding what T-cells perform can help you better understand CAR T-cell therapy.

  • Lymphocytes are white blood cells that aid in the fight against infection and disease, including cancer.
  • Lymphocytes come in a variety of shapes and sizes. T-cells are one of the same types.
  • T-cells search the body for defective cells and destroy them. When you come into contact with a new virus or disease, your body produces T-cells to help you fight it. It then keeps some back in reserve so that if you get infected again, your body will recognize it and attack it right away.

Who is the suitable candidate for CAR T-Cell Therapy?

The FDA has approved CAR T cell therapy for patients who have relapsed/recurred or progressed after receiving previous treatments for certain types of leukemia or lymphoma. The patient must have previously failed at least two standard cancer therapy to be eligible for the CAR T-cell therapy in India.

Children and adults up to the age of 25 with advanced and relapsed or refractory acute lymphoblastic leukemia, as well as adults with aggressive and recurring large B-cell non-Hodgkin lymphomas that have not been totally eradicated after at least two prior cancer therapy.

What types of cancer can be treated with Car T-Cell Therapy?

The FDA has approved CAR T-cell therapies for the treatment of B-cell non-Hodgkin lymphomas (white blood cell cancer) in adults and Acute Lymphoblastic Leukemia (ALL) in children and young adults. The two FDA-approved therapies are:

  • Tisagenlecleucel (Kymriah®): It is the first CAR T cell therapy to receive FDA approval, and it is used to treat advanced B-cell Lymphoblastic Leukemia in children and young adults.
  • Yescarta (Axicabtagene Ciloleucel):  It is approved for adult patients with large B-cell non-lymphoma Hodgkin’s that has returned or has not responded to traditional treatments.

Other types of blood cancers are being treated using Car T-Cell Therapy in a number of clinical trials, including:

 

Car T-Cell Therapy Cost in India

Car T-Cell Therapy Cost in India starts from USD 384000.

Aside from the initial cost of CAR T-cell therapy, there is an additional financial burden that is sometimes underestimated. This includes a variety of out-of-pocket charges for patients and their caregivers, such as accommodation and transportation.

Procedure

How Does The Therapy Perform?

Before starting the therapy, the doctor will do a series of tests to see if the patient is a good candidate for it. The steps in the treatment process are as follows:

Collection of T-cells from the patient: A procedure called apheresis is used to collect T cells from the patient. It entails extracting blood from the patient and eliminating specific blood components, in this case, T-cells. The blood that remains is returned to the body.

Bioengineering of the T-Cells: T-cells are genetically altered to express chimeric antigen receptors (CARs) on their surface after being taken from the blood and transported to the lab for bioengineering.

Increasing the number of CAR T cells: In the laboratory, the number of modified CAR T cells is increased until there are millions of them. After that, the cells are frozen and transported to the hospital. This procedure could take 2 to 6 weeks to complete if there are enough participants.

Conditioning: Around 1 or 2 weeks before the new cells are given, the patient comes to the hospital for a brief course of chemotherapy with lympho-depleting medications. This process is carried out to clear the immune system of normal T cells and make room for CAR T-cells to grow.

Re-infusion of the cells: The CAR T-cells are frozen in the hospital and then infused into the patient’s bloodstream via a process similar to blood transfusion. These cells are then permitted to develop and proliferate in the patient’s body.

What are the Possible Side-Effects of Car T-Cell Therapy?

CAR T-cell treatment can be very effective against certain types of tough cancers, but it can also have severe or even fatal side effects. As a result, it must be administered at a medical facility that is properly skilled in its usage, and patients must be constantly monitored for several weeks after receiving CAR T-cells therapy

Cytokine release syndrome (CRS): CAR T-cells can release large amounts of molecules called cytokines into the bloodstream as they multiply, which can stimulate the immune system. The following are major side effects that may occur as a result of this release:

  • Chills with a high fever
  • Breathing problems
  • Symptoms include severe nausea, vomiting, and/or diarrhea.
  • Feeling lightheaded or dizzy
  • Headaches
  • Fast heartbeat
  • Extreme tired feeling
  • Pain in the muscles and/or joints

Doctors are learning how to diagnose CRS early and how to treat it as they get more expertise with CAR T-cell therapy.

Nervous system issues: This treatment can have substantial side effects on the nervous system, resulting in symptoms like:

  • Headaches
  • Consciousness changes
  • Mood swings, confusion, or agitation
  • Seizures
  • Twitching or shaking (tremors)
  • Speaking and understanding problems
  • Loss of balance

Adult patients are often advised not to drive, operate heavy machinery, or engage in any other potentially risky activities for at least several weeks after receiving therapy due to the risk of these side effects.

Conclusion

The early outcomes of CAR T-cell therapy for patients with blood cancers have been outstanding in clinical trials using chimeric antigen receptor T-cells.

Up to 90% of children and adults with specific cancers who had relapsed or failed to respond to traditional medicines achieved remission after undergoing CAR T-cell therapy, according to certain studies. Relapses may occur as a result of tumor cells losing their expression of the cluster of differentiation (CD-19) antigen, CAR T cell persistence being reduced, or CAR T-cell activity is inhibited.

CAR T-cell therapy has also shown potential in other blood cancers, such as chronic lymphocytic leukemia (CLL) and multiple myeloma. CAR T-cell therapy is also being researched for use in the treatment of cancer.

The Most Important Frequently Asked Questions

Q: What is the CAR T-cell therapy success rate?

A: According to the Cancer research department, the CAR T-cell therapy success rate is around 30% to 40% for long-term remission with no additional treatment.

Q: Is CAR T-cell therapy a more effective treatment than chemotherapy?

A: CAR T-cell treatment may eventually be able to completely replace chemotherapy and stem cell transplants. However, we must first demonstrate that it is at least as successful as — if not more effective than — those medicines.

Q: How long do you have to stay in the hospital for CAR-T therapy?

A: Most people need to stay in the hospital for a week to ten days so that their doctors can evaluate their progress and manage any side effects. You might be able to get CAR-T cells without staying in the hospital.

Q: What are the disadvantages of using CAR T cells?

A: While the medication can help some patients with advanced cancer achieve long-term remissions, it can also bring neurologic adverse effects such as speech issues, tremors, psychosis, and seizures. Some of the negative effects might be dangerous or even fatal.

Q: How long does it take for CAR-T therapy to work?

A: The risk/recovery period for patients who get CAR T-cell treatment is approximately 2-3 months. Patients will be monitored for adverse effects and treatment responses during this time. Patients are frequently admitted to the hospital during this time to deal with issues.

 

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Medsurge India is one of the pioneers and the most reputable company in the field of medical tourism in India. India offers World Class Medical Facilities, comparable with any of the Western and European countries. India has state of the art Hospitals and the finest medical experts. With the most excellent infrastructure, the best possible Medical facilities, accompanied with the most competitive prices, you can get the treatment done in India at the lowest charges. The Availability of Ayurveda and Naturopathy in the purest form makes India the most sought after health destination.

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